Stops tumor growth: scientists have created a new cure for cancer

The drug, which can stop the recovery of cancer cells, showed the first signs of effectiveness, writes Air force.

Photo: Shutterstock

More than half of the 40 patients receiving berzosertib, cancerous growths stopped growth.

Berzosertib was even more effective when it was prescribed in parallel with chemotherapy, as studies conducted by the Cancer Research Institute (ICR) and Royal Marsden NHS Trust have shown.

The test was designed to verify the safety of the drug.

The drug is the first tested tool in a new group of treatments that block the protein involved in DNA repair.

Blocking this protein prevents cancer damage to cells.

This is part of the industry known as “targeted therapy,” aimed at specific genes or genetic changes.

The study involved patients with very complex tumors for which there was no other treatment.

The test was called the "first phase", intended only to verify the safety of treatment.

But the ICR said researchers found some early signs that berseroside can stop tumor growth.

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"Very promising"

Chris Lord, one of the authors of the study, professor of cancer genomics at the ICR, said that these early signs were “very promising,” adding that it was unusual to see a clinical response in the first phase of the study.

However, further testing is needed to demonstrate the effectiveness of the drug.

"This study only included a small number of patients... So it is too early to consider berzosertib a game-changer in cancer treatment," said Dr Darius Vaidera, from the University of Reading. “However, the unusually strong effects of berzozertib, especially when combined with conventional chemotherapy, provide reason for optimism about the results of subsequent studies.”

Philip Mulling, 62, who was diagnosed with bowel cancer in 2012, was enrolled in the study after two years of unsuccessful chemotherapy.

“They told me, ‘We can’t do anything more for you,’” he shares. “I was told in April 2014 that I would probably be dead by Christmas.”

He is currently being treated with berzosertib for six years, his tumors have shrunk, and his condition is stable.

"It means everything to me," Malling told the BBC.

In another patient, whose ovarian cancer returned after the next course of treatment, the tumors decreased after combined treatment with the drug and chemotherapy.

Chemotherapy works by damaging the DNA of cancer cells, so using it in combination with this new treatment that keeps cells from self-healing is even more beneficial.

According to Professor Lord, berzosertib is able to act on tumor cells without affecting other healthy cells.

“Our new clinical trial is the first to test the safety of a new family of targeted cancer drugs in humans and it is encouraging to be able to see some clinical responses even at this early stage,” said Professor Johann de Bono, Head of Medicines at the ICR and Royal Marsden.

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In the future, these drugs can be used to “enhance the effect of procedures such as chemotherapy” and to overcome resistance that may develop to other targeted treatments, he added.

Whereas the traditional approach to treating cancer is to classify it by tumor site—breast cancer, lung cancer, and so on—a “targeted therapy” approach targets the genetic abnormality in the tumor, no matter where it is. located.

Targeted approaches are already being used, for example, in prostate cancer, to block the action of the hormone testosterone, which is involved in tumor growth.

If used alone, it may provide a less aggressive option than chemotherapy, which acts on the cells indiscriminately.

The next phase of the berzosertib test has already begun.

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