In Russia, 40 mutations of coronavirus were found in the body of one woman: she was continuously ill for almost a year

Russian scientists have discovered 40 mutations of coronavirus infection in the body of a patient with lymphoma. All this happened over a period of 318 days. The edition told in more detail New Time.

Photo: Shutterstock

COVID-19, which was first detected in China at the end of 2019, has grown with new strains during its worldwide spread. Coronavirus can mutate not only in the human population, but even in the body of one person, if the infection lasts long enough, for example, with weakened immunity.

Some of these mutations are aimed at simplifying penetration into the cell, accelerating from antibodies or reducing the recognition of immunity by cells, in the future, they can create problems with the effectiveness of vaccines and complicate the course of the disease.

Russian scientists led by Georgy Bazykin from the Kharkevich Institute for Information Transmission Problems described a case of the development of multiple mutations of the coronavirus in a woman suffering from non-Hodgkin's B-cell lymphoma, a malignant disease of the lymphatic system.

On the subject: Estonia has created a spray that protects against all strains of COVID-19: it is already on sale

The patient was first diagnosed with COVID-19 on April 17, 2020. After that, her positive tests alternated with negative ones for 318 days, during which time she developed pneumonia twice - in the summer of 2020 and in the winter of 2021.

During this period, the patient underwent several courses of chemotherapy. Six samples from the nasopharynx were taken from the woman (in August 2020 and in January 2021) and full genome sequencing of the coronavirus was performed. This procedure was also performed on the person from whom the patient contracted COVID-19.

You may be interested in: top New York news, stories of our immigrants and helpful tips about life in the Big Apple - read it all on ForumDaily New York

In general, the patient's virus developed 40 mutations, 34 of which occurred at the end of observations. This exceeds the mutation rate in the general population. Of the 40 mutations, 12 interfered with the recognition and neutralization of the coronavirus by T cells. This is due to the fact that due to the tumor, the woman's immunity was weakened, and only T-lymphocytes functioned normally, therefore 12 of the detected mutations helped the virus bypass the T-cell immune response.

To assess the patient's immune response, a blood test was taken. No mature B-lymphocytes were found in her plasma, a small amount of IgG antibodies was found, but only in one of the samples. At the same time, scientists observed a strong T-cell response to the coronavirus.

The researchers speculate that the coronavirus in a woman with lymphoma mutated in a targeted manner to avoid T-cell immunity, as other types of immunity were weakened due to cancer of the lymphatic system.

Read also on ForumDaily:

In the USA, a report was published that the coronavirus 'escaped' from a Chinese laboratory: what is the document about

Estonia has created a spray that protects against all strains of COVID-19: it is already on sale

Stroke is 'getting younger': how you can reduce your risk of cerebral hemorrhage

California obliges all civil servants and health workers to be vaccinated against COVID-19

Do you want more important and interesting news about life in the USA and immigration to America? — support us donate! Also subscribe to our page Facebook. Select the “Priority in display” option and read us first. Also, don't forget to subscribe to our РєР ° РЅР ° Р »РІ Telegram  and Instagram- there is a lot of interesting things there. And join thousands of readers ForumDaily New York — there you will find a lot of interesting and positive information about life in the metropolis.