In Russia, 40 mutations of coronavirus were found in the body of one woman: she was continuously ill for almost a year
Russian scientists have discovered 40 mutations of coronavirus infection in the body of a patient with lymphoma. All this happened over a period of 318 days. The edition told in more detail New Time.
COVID-19, which was first detected in China at the end of 2019, has grown with new strains during its worldwide spread. Coronavirus can mutate not only in the human population, but even in the body of one person, if the infection lasts long enough, for example, with weakened immunity.
Some of these mutations are aimed at simplifying penetration into the cell, accelerating from antibodies or reducing the recognition of immunity by cells, in the future, they can create problems with the effectiveness of vaccines and complicate the course of the disease.
Russian scientists led by Georgy Bazykin from the Kharkevich Institute for Information Transmission Problems described a case of the development of multiple mutations of the coronavirus in a woman suffering from non-Hodgkin's B-cell lymphoma, a malignant disease of the lymphatic system.
The patient was first diagnosed with COVID-19 on April 17, 2020. After that, her positive tests alternated with negative ones for 318 days, during which time she developed pneumonia twice - in the summer of 2020 and in the winter of 2021.
During this period, the patient underwent several courses of chemotherapy. Six samples from the nasopharynx were taken from the woman (in August 2020 and in January 2021) and full genome sequencing of the coronavirus was performed. This procedure was also performed on the person from whom the patient contracted COVID-19.
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In general, the patient's virus developed 40 mutations, 34 of which occurred at the end of observations. This exceeds the mutation rate in the general population. Of the 40 mutations, 12 interfered with the recognition and neutralization of the coronavirus by T cells. This is due to the fact that due to the tumor, the woman's immunity was weakened, and only T-lymphocytes functioned normally, therefore 12 of the detected mutations helped the virus bypass the T-cell immune response.
To assess the patient's immune response, a blood test was taken. No mature B-lymphocytes were found in her plasma, a small amount of IgG antibodies was found, but only in one of the samples. At the same time, scientists observed a strong T-cell response to the coronavirus.
The researchers speculate that the coronavirus in a woman with lymphoma mutated in a targeted manner to avoid T-cell immunity, as other types of immunity were weakened due to cancer of the lymphatic system.
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