Doctors in the US managed to defeat stage four cancer
Thanks to the new procedure, American scientists managed to cure breast cancer in a woman at the last stage, this is stated in a new study published in the journal Nature, writes with the BBC.
As part of the new therapy, 90 billion immune cells were introduced into the bloodstream of women.
Two years ago, doctors told Judy Perkins from Florida that she had three months to live. Today in her body there is no trace of a cancerous tumor.
A team of scientists from the National University of Cancer in the USA says that such therapy is still experimental, but over time it can become a method of treating all types of cancer.
In Judy, there was terminal cancer of the breast - it spread quickly and was not subject to conventional treatment.
There were tumors the size of a tennis ball in her liver, and metastases spread throughout her body.
She told reporters about her experience in experimental treatment: “About a week after the start of therapy, I began to feel something. There was a swelling in my chest, and I felt it shrink. In one or two weeks she completely disappeared. "
She also recalls the first tomogram after the procedure - all the medical staff “was very excited and even jumped up”.
Then she was informed that she was completely healthy.
Judy now goes camping and kayaking, and has recently traveled around her home state for five weeks.
The procedure, in fact, is like “living medicine” that is made from the cells of the patient himself in one of the world's leading cancer research laboratories.
“It's about the most personalized treatment you can imagine,” said Dr. Stephen Rosenberg, head of the Department of Surgery at the National Cancer Institute in the United States
So far, such treatment is experimental, and requires a lot of tests and checks before it is used everywhere.
But here is how it works.
It all starts with the study of the enemy.
The patient’s tumor is analyzed at the genetic level to identify rare genetic changes that can make the cancer visible to the immune system.
With 62 genetic abnormalities in the tumor of the patient, Judy Perkins, only four could become potential targets for an immune attack.
The next stage is hunting. The patient’s immune system is already starting to attack the tumor, but white blood cells still lose to cancer cells.
At this stage, scientists closely monitor the patient’s white blood cells and isolate those that can successfully attack the cancer. They are then grown in large quantities in laboratories.
About 49 billion of such artificially propagated immune cells have been injected into the blood of an 90-year-old Judy, along with medicines that “take the brakes” off the immune system.
“The same mutations that cause cancer become its Achilles heel,” said Dr. Rosenberg.
"Change of paradigm"
These are the results of treatment for only one patient. To confirm the findings, scientists have to conduct large-scale medical research.
The challenge so far is that immunotherapy in cancer treatment can work phenomenally for some patients - and not at all bring any benefit to others.
“This is a very experimental treatment, and we are only learning how to carry it out, but it can potentially be applied to any type of cancer,” says Dr. Rosenberg. “We still have a lot of work to do, but there is the potential for a complete paradigm shift in cancer treatment - to create a unique medicine for each patient - and this is very good for all types of treatment.”
The research of American colleagues was praised by Dr. Simon Vincent of the British charity research laboratory Breast Cancer Now.
“We think these results are outstanding. This is the first opportunity to see this type of immunotherapy on the most common form of cancer. But so far it has been tested on only one patient, ”notes Dr. Simon.
“There is still a lot of work to be done, but potentially this technology could open up a whole new branch of therapy for a large number of people,” he concludes.
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