In the United States began to test the HIV vaccine on people: how it works

The company announced that the first participants have been vaccinated as part of a phase 1 clinical trial of an experimental HIV vaccine that uses Moderna mRNA technology. CNN.

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Test titled IAVI G002 is being held in partnership with IAVI, a non-profit research organization. This is a test of a vaccine that delivers specific HIV antigens to the body in order to elicit an immune response. These antigens were originally developed by IAVI and Scripps Research led by Dr. William Schiff.

Last year, in a proof-of-concept trial, the research team found that HIV antigens elicited the desired immune response in 97% of participants. The current test builds on the previous one. Scientists are testing the main version of the vaccine, as well as a booster version, and are also using Moderna mRNA technology, which has previously been used to create a successful Covid-19 vaccine.

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“We are very excited to advance this new direction in HIV vaccine development with the Moderna mRNA platform. The search for an HIV vaccine has been long and complex, and having new tools in terms of immunogens and platforms could be the key to rapid progress toward an effective HIV vaccine,” said Mark Feinberg, President and CEO of IAVI, in a Moderna press release. .

The new trial, funded in part by the Bill & Melinda Gates Foundation, will involve 56 HIV-negative adults to study both the safety and efficacy of the vaccine. Forty-eight volunteers will receive at least one dose of the primary vaccine, 32 of whom will also receive a booster. The remaining eight will receive only the booster vaccine.

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The trial involves volunteers from four locations: The George Washington University School of Medicine, Hope Clinic, Emory Vaccine Center, Fred Hutchinson Cancer Research Center, and the University of Texas Health Sciences Center at San Antonio.

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