Moderna destroyed 400 thousand doses of COVID-19 vaccine: what happened

An official said that Moderna Inc. 400 doses of COVID-000 vaccine had to be destroyed. The resulting filtration problem spoiled the product in the final stages of production. Writes about it Bloomberg.

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Moncef Slaoui, chief scientific adviser to Operation Warp Speed, spoke about the production glitch. The 400 doses that have not yet been put into vials are part of a larger vaccine shipment of 000 million doses, Slaoui said.

Despite the challenge, Moderna is still on track to meet its 20 million dose production targets this month and 85 million to 100 million doses for the U.S. in the first quarter of 2021, according to Ray Jordan, a Cambridge, Mass. ...

The Moderna vaccine uses messenger RNA technology similar to that used in the Pfizer vaccine.

The loss of 400 doses is something of a drop in the bucket for Moderna's overall goal of producing 000 million to 500 billion doses in 1. Slaoui, an immunologist and former pharmaceutical industry executive, said the filtration issue is just one of many examples of how companies must monitor their production lines and solve problems in real time.

These are the challenges to be expected with a complex manufacturing process like the one required for the Moderna vaccine, Sloughie said. According to him, this issue will not affect the overall production or production rates.

On the subject: Pfizer Releases COVID-19 Vaccine Side Effects Report

“In my experience, the process runs as smoothly as any manufacturing process I have seen in my 30-year career in the industry,” says Slaoui.

Drug manufacturers usually stockpile a new product before launching it on the market, he said. But in this case, he said, "it would be unethical."

Glass vials

Moderna is collaborating with the National Institute of Allergy and Infectious Diseases, a division of the National Institutes of Health, to develop a COVID-19 vaccine, and has turned to US Operation Warp Speed's vaccine development program for financial and logistical support.

The government has taken steps to ensure that Moderna does not face impediments to supply from contractors.

As for Moderna, “we've been told we're ahead of most on the supply chain schedule. This is good and bad. Sometimes they tell us they don't have a place to put our vials and ask us to hold them for a day or another week,” said Lawrence Ganti, president and chief commercial officer of SiO2 Material Science.

Zoom in

Moderna has signed agreements with Lonza Group AG to expand dose production at facilities in Portsmouth, New Hampshire and Wisp, Switzerland, and with Catalent Inc., which fills, packs vaccine vials for distribution at its Bloomington, Indiana facility. , and with the Laboratorios Farmacéuticos Rovi factory in Madrid for operations outside the United States. SiO2 provides vials.

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So instead of shipping the vials in one weekly shipment, the company ships them in smaller trucks three to four times a week to fill the vial as space becomes available.

“These are little things and they don’t affect the overall situation, but these little things are very annoying,” he explained.

For Moderna, SiO2 produces up to 40 million vials, each of which can hold 8 to 10 doses of vaccine.

“Theoretically, there will be enough for a couple of hundred million doses,” Lawrence Ganti said. His company will produce 12 million vials for Moderna by the end of this week, all of which will be used to fill U.S. supply orders.

“The first batch of vials is intended exclusively for the United States, this is a priority,” said the president and chief commercial officer of SiO2 Material Science.

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