Japanese startup has created a drug for growing new teeth - ForumDaily
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Japanese startup has created a drug for growing new teeth

A group of scientists led by a Japanese pharmaceutical startup is working to create a drug that stimulates the growth of new teeth. This is the first drug of its kind in the world. If all goes well, the company plans to bring it to market around 2030. The publication told in more detail ABS CBN.

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Toregem Biopharma Co., funded by Kyoto University, plans to begin clinical trials in healthy adults around July 2024 to confirm the drug's safety, after the team succeeded in growing new teeth in mice in 2018.

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Most people, in addition to their primary and permanent teeth, have “tooth buds” that can potentially become a new tooth, but these buds usually do not develop and subsequently disappear.

The team has created an antibody drug that inhibits a protein that inhibits tooth growth. The drug acts on these kidneys and stimulates their growth.

In 2018, the team injected the drug into ferrets, which, like humans, have baby and permanent teeth, and grew new teeth.

The team plans to conduct clinical trials of the drug from 2025 on children aged 2 to 6 years with anodontia, who are born without some or all of their permanent teeth. Children will be given one dose of the drug to cause teeth to grow.

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It is hoped that in the future the drug will be used for adults who have lost teeth due to tooth decay.

“A child's missing teeth can affect the development of his jawbone,” says Katsu Takahashi, co-founder of Toregem Biopharma and director of the department of dentistry and oral and maxillofacial surgery at Kitano Hospital in Osaka. “We hope that this drug will be the key to solving such problems.”

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