It provokes a strong immune response: the American vaccine from COVID-19 encouraged scientists
Moderna's stock soared after it announced that a potential vaccine to prevent COVID-19 elicited a “strong” immune response in all 45 patients in the early stages of human trials. Writes about this CNBC.
Moderna shares rose more than 16%.
All 45 patients developed neutralizing antibodies, which, according to scientists, are important for creating immunity. This gives hope that the vaccine may provide some protection against coronavirus. In the study, each participant received a dose of 25, 100 or 250 micrograms, 15 people in each group. Participants received two doses of a potential vaccine.
According to a company representative, after two vaccinations, the vaccine provoked a “strong” immune response in all participants. The company said that neutralizing antibody levels in patients in the high-dose group were four times higher than in recovered patients with COVID-19.
“These phase 1 data demonstrate that mRNA-1273 vaccination elicits a stable immune response regardless of dose. The company chose 100 mcg as the optimal dose for the Phase 3 trial, ”said Moderna Chief Medical Officer Tal Sachs. “We look forward to starting the phase 3 mRNA-1273 study this month to demonstrate our vaccine’s ability to significantly reduce the risk of COVID-19.”
In May, the company released preliminary information about the early stages of testing, but the data were insufficient, and therefore the study has not yet been reviewed.
The company said the vaccine was generally well tolerated, but more than half of the participants reported mild or moderate symptoms, such as fatigue, muscle pain, or pain at the injection site.
Evaluation of the resistance of the immune response continues, and participants will be monitored for one year after vaccination.
According to data compiled by Johns Hopkins University, Moderna is one of several developers of a potential vaccine against COVID-19. According to the World Health Organization (WHO), more than 100 vaccines are being developed in the world.
Moderna previously announced that it will begin testing the vaccine on July 27. The study will bring together 30 participants in 000 cities. Participants in the experimental group will receive a dose of 87 μg of the potential vaccine on the first day and after another 100 days. Some patients will also receive a placebo.
Moderna's experimental vaccine contains genetic material called messenger RNA or mRNA. mRNA is a genetic code that tells cells what they need to build - in this case, it is an antigen that can trigger an immune response to the virus.
Scientists are still studying key aspects of the virus, including how the immune system reacts when a person becomes infected. The answers, they said, could have important implications for developing a vaccine, including how quickly it could be distributed to the public.
The United States plans to distribute 300 million doses of the COVID-19 vaccine by early 2021.
Dr. Anthony Fauci, the country's leading infectious disease specialist, has often praised the potential vaccine for Moderna. He said scientists could create at least one safe and effective vaccine by the end of the year or early 2021.
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