In the United States created a vaccine against COVID-19 based on the avian plague virus

Another drug, which is a candidate for anti-coronavirus vaccines, was developed by American biologists at the University of North Carolina, writes Liga.net.

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In the United States, a vector vaccine against SARS-CoV-2 was tested on “humanized” mice, based on the LaSota strain of Newcastle disease virus (NDV), which was upgraded with the coronavirus S-protein. The result was posted on the bioRxiv preprint server.

The experiments were carried out in the laboratory of the 3rd, maximum level of biosecurity.

Nine groups of mice were immunized with four different variants of the vaccine at a dosage of 10 and 50 μg according to a three-week prime-boost scheme (first vaccination + fixing). The injections were done intramuscularly because live NDV hardly replicates in muscle and does not cause symptoms in mammals.

Newcastle disease, or Asian avian plague, is a viral disease of birds. They develop pneumonia, encephalitis and multiple pinpoint hemorrhages in the organs. The pathogen RNA paramyxovirus poses a great threat to poultry due to its high sensitivity to the virus and mortality rate of 15-30%.

The virus is harmless to humans: the maximum can cause mild conjunctivitis and flu-like symptoms.

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The authors claim that their drug "induced high levels of neutralizing antibodies" at all doses. An attempt to infect immunized animals with coronavirus nasally (through the nose) was futile: the virus itself and its antigens were not detected in the lungs after such an experiment.

It is proposed to produce this vaccine in a traditional and relatively cheap way for many similar drugs - in chicken eggs with embryos.

NDV is a safe vaccine platform. This virus is also used for research into the development of antitumor vaccines: it can selectively infect cancer cells.

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