The first child with antibodies to COVID-19 was born in the USA: how is this possible

The first child in the United States was born with antibodies against COVID-19 after mom received a dose of Moderna vaccine during pregnancy. The edition told in more detail CBS News.

At 36 weeks pregnant, a South Florida healthcare professional received her first dose of Moderna COVID-19 vaccine. Three weeks later, she gave birth to a healthy baby girl with antibodies to this type of coronavirus.

Doctors believe the newborn is the first known birth of a child in the United States with antibodies to COVID-19.

Dr. Paul Giblert and Dr. Chad Rudnik found the antibodies were found during labor after testing a blood sample from the baby's umbilical cord taken immediately after birth and before delivery.

“We found that IgG antibodies to SARS-CoV-2 are detectable in a newborn umbilical cord blood sample after a single dose of the Moderna vaccine,” they concluded. “Therefore, there is potential for protection and reduction in the risk of infection with the Sars-CoV-2 virus when the mother is vaccinated.”

However, doctors emphasize that more research is needed to test the safety and efficacy of coronavirus vaccines during pregnancy.

It was already known that mothers previously infected with COVID-19 can transmit antibodies to their young. In addition, the transmission of antibodies from mother to child through the placenta has been well documented in other vaccines, including influenza, so doctors hoped that the same protection for newborns would be possible after the mother was vaccinated against COVID-19.

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“This is really the beginning of aligning the COVID-19 vaccine with the vaccines that we already use in pregnant women, like the flu vaccine,” said Dr. Nita Ogden, an internal medicine specialist and immunologist. “We need serious data on how safe it is.”

These early results may give pregnant women more reason to consider getting vaccinated.

“This is encouraging because it provides some level of protection for one of the most vulnerable populations: newborns,” Ogden said, but stressed the need for further study.

Since there are no approved childhood vaccines against COVID-19 yet, she is convinced: "If we can see such a safe transfer of maternal antibodies from the vaccine to newborns, then in my opinion, this is really a big step in the right direction."

Other recent studies, published in the preprint and not peer reviewed, support the findings.

Massachusetts Hospital recently examined 131 women: 84 pregnant, 31 breastfeeding, and 16 non-pregnant. They all received Pfizer or Moderna vaccines. Equally strong immune responses were found both in pregnant and lactating women and in the control group. In addition, antibodies were present in the placenta and breast milk of each sample taken.

“Antibodies produced by the maternal vaccine were detected in the umbilical cord blood of all 10 babies born during the study period,” said co-author Dr. Andrea Edlow, a maternal-fetal medicine specialist at Massachusetts General Hospital. “Our data shows that receiving both injections of the mRNA vaccine results in improved antibody transfer to newborns.”

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Another study in Israel found antibodies in all 20 women tested who received both doses of Pfizer vaccine.

In February, Pfizer announced that it had begun the first large-scale trial of its vaccine in pregnant women, which is expected to be completed by early 2023. Her vaccine was approved for emergency use in the United States in December, and millions of people, including thousands of pregnant women, have already been vaccinated.

Johnson & Johnson, which was approved for emergency use of the vaccine in February, said it plans to include pregnant women and their babies in its studies and collect data on pregnant women through the registry.

Note that pregnant women were excluded from the initial trials of the Moderna and Pfizer COVID-19 vaccines, which is common practice in such studies.

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