Scientists have discovered 'invincible' antibodies to coronavirus: they neutralize all its strains

With the light hand of biologist Jay Nicks, a new treatment with antibodies to all strains of SARS-CoV-2 and other coronaviruses has appeared. Sci-Tech Daily.

Photo: Shutterstock

The vaccine, a life-saving COVID-19 vaccine, has brought a ray of hope to our world, which has been in a state of anxiety and stress for almost a year.

But vaccination is only one side of the coin, and we also need treatment that will prevent the spread of serious infectious diseases.

In recent years, medicine has made colossal breakthroughs in the development of antibody-based treatments. There are three drugs currently approved by the Food and Drug Administration.

The latest modern treatment, which was the fruit of the joint international work of scientists, is based on the discovery of natural antibodies in the blood of those who have successfully recovered from SARS in 2003. These large-scale studies have been of immense benefit.

Experiments have shown that these antibodies (called S309) kill all known strains of SARS-CoV-2 - including newly emerging mutating viruses that have not worked against previous treatment with antibodies.

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Jay Nix, head of the molecular biology association, using two devices (one Berkeley laboratory device is a modern a beam dispenser (ALS) and another - an apparatus from the Stanford Synchrotron Radiation Laboratory) obtained x-rays of examples of antibodies in the early stages of study. His work with crystallography and cryoelectronic research helped answer the question of how these antibodies are related to SARS-CoV-2. and the growth of their corresponding proteins. This made it possible to identify the most "promising" antibodies and to continue research on animals in laboratory conditions. The S309 structure has been approved for clinical trials.

At the end of May, clinical trials showed that a group of patients infected with COVID-19 in the mild to moderate stages, after receiving treatment, decreased death and hospitalization rates by 85% compared to the placebo group.

But the team of scientists didn't stop there.

It was clear that the process of mutation of viruses is endless. Therefore, scientists began to study more deeply the mechanisms of antibodies, namely why antibodies react so actively to viruses of the same type. Using biochemical and structural analyzes, as well as a deep mutation scanner, and conducting many related experiments, they discovered "super-antibodies" that have enormous and at the same time universal potential.

“These antibodies appeared to destroy all known viruses that cause respiratory problems and give complications to the lungs, ”says Nix. He hopes that thanks to this discovery by mutating strains will have a much harder time eluding treatment.

Further testing in rodents has shown that these antibodies can even prevent COVID-19 disease if treated prophylactically.

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