Scientists have found a way to permanently destroy a cold - ForumDaily
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Scientists have found a way to permanently destroy a cold

Scientists believe that they have found a way to stop the common cold and closely related viruses, which can lead to paralysis.

Фото: Depositphotos

Researchers drew attention to the key protein inside our cells that viruses need in order to multiply.

This approach gave a positive result in experiments on mouse cells. However, American researchers are not yet ready for human trials.

The fight against colds has become a massive problem in medicine.

Most of these diseases are caused by rhinoviruses. They exist around 160 of various types. These viruses mutate so easily, quickly become resistant to drugs and learn to hide from the immune system.

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This led to the idea of ​​creating "host-directed therapies" - that is, we are talking about making our body invulnerable to these viruses.

A team from Stanford University and the University of California at San Francisco found one of the components that viruses depend on.

Viral addiction

Scientists began working with human cells, and then used gene editing to turn off instructions inside our DNA.

These modified cells were then exposed to a range of enteroviruses - these include rhinoviruses, which cause the common cold, and more dangerous viruses that are closely related to polio and can cause paralysis.

All viruses could not replicate inside cells in which protein instructions were turned off.

Scientists then created genetically modified mice that are unable to produce this protein.

Фото: Depositphotos

“The absence of this gene completely protected the mice from viral infection,” said assistant professor Ian Kerrett of Stanford.

“These mice always died [without the mutation], but now they survived, and we saw a very strong reduction in viral replication and very strong protection.”

Results published in the journal Nature Microbiology , showed that genetically modified mice were healthy, despite the fact that they lacked protein throughout life.

When will the medicine be?

The plan is not to produce genetically modified people, but to look for a drug that can temporarily suppress protein and protect the body.

“We have identified a fantastic target that all enteroviruses and rhinoviruses depend on. If you remove it, the virus really has no chance,” Professor Caretto said.

He added: "This is a really good first step, the second step is to get a chemical that mimics this genetic erasure."

“I think development can happen relatively quickly.”

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The role of protein in viral replication remains uncertain and requires further research.

For most people, the common cold is more of an inconvenience than a threat to their health. But there are asthmatics for whom these viruses make their symptoms worse, and some enteroviruses can cause paralysis if they spread to the brain.

Professor Jonathan Ball, a virologist at the University of Nottingham who did not participate in the study, said it was good, but scientists need to make sure this approach is safe.

“There is growing interest in developing treatments that target these “host proteins,” as this could potentially overcome viral mutation—one of the main barriers to the development of effective, broadly active antiviral drugs.

“But, of course, viruses are very adaptable, and it may be that even host-targeted treatments will stymie them for only a short time.”

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