'Saves lives around the world': a cheap and popular drug reduces mortality from COVID-19 - ForumDaily
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Bu məqalə Google Translate servisi vasitəsi ilə avtomatik olaraq rus dilindən azərbaycan dilinə tərcümə olunmuşdur. Bundan sonra mətn redaktə edilməmişdir.

'Save lives around the world': a cheap and popular drug reduces mortality from COVID-19

A cheap and widely available drug can help save the lives of patients seriously ill with coronavirus infection, reports Air force.

Photo: Shutterstock

British experts say that low doses of steroid hormone dexamethasone are a major breakthrough in the fight against the deadly virus.

Препарат — часть крупнейшего в мире пробного испытания существующих методов лечения, призванного определить, работают ли они также в отношении коронавирусной инфекции.

The drug reduced the risk of death by one third for patients on the ventilator. For those on oxygen, he reduced the number of deaths by one fifth.

According to the researchers, if this drug was used to treat patients in the UK from the start of a pandemic, up to 5000 lives could be saved.

And this can be of great benefit in poorer countries with more patients with COVID-19.

British Prime Minister Boris Johnson said that this is a real occasion to celebrate "a remarkable British scientific achievement," adding: "We have taken steps to ensure sufficient reserves even in the case of a second peak."

England's chief medical officer, Professor Chris Whitty, said the discovery would save lives around the world.

About 19 out of 20 patients with coronavirus recover without hospitalization. Of those who were admitted to the hospital, most also recover, but some may need oxygen or mechanical ventilation.

On the subject: 'Will not save you from infection': the rush to create a vaccine against coronavirus can affect its quality

And these high-risk patients seem to be helped by dexamethasone.

The drug is already being used to reduce inflammation in several other conditions, including arthritis, asthma, and certain skin conditions. It seems that it can also stop some damage that can occur when the body's immune system begins to overload, trying to fight the coronavirus.

This overreaction, the so-called cytokine storm, can be fatal.

В исследовании, проводимом командой из Оксфордского университета, около 2000 пациентов больницы получали дексаметазон, а более 4000 — нет. Для пациентов, находящихся на аппарате ИВЛ, он снижает риск смерти с 40% до 28%. Для пациентов, нуждающихся в кислороде, он снижает риск смерти с 25% до 20%.

Chief Investigator Professor Peter Horby said: “So far, this is the only drug that reduces mortality, and significantly. This is a big breakthrough. ”

Leading researcher Professor Martin Landray said that, as the results show, you can save:

  • 1 out of 8 patients on a ventilator;
  • 1 out of 20-25 lives of those who receive oxygen.

«Есть явное, явное преимущество, — сказал он. — Лечение дексаметазоном составляет до 10 дней, и оно стоит около 5 фунтов стерлингов ($6,28) на пациента. Так что по сути спасение жизни стоит 35 фунтов ($44). Это препарат, который доступен во всем мире».

According to Professor Landrey, when appropriate, hospital patients should now be given it without delay. But people should not go out and buy it to take home.

Dexamethasone does not appear to help people with milder symptoms of coronavirus who don't need breathing help.

The trial, which has been conducted since March, also examined the drug hydroxychloroquine, which is intended for the treatment of malaria, which was subsequently ruled out because of fears that it will increase mortality and heart problems.

Meanwhile, it is noted that the antiviral drug remdesivir appears to reduce the recovery time of people with coronavirus.

On the subject: He was accepted by Trump: in the USA, permission to treat COVID-19 with hydroxychloroquine was revoked

Analysis by Fergus Walsh, Air Force Health Correspondent

Первое лекарство, доказанно снижающее смертность от COVID-19 — это не какое-то новое, дорогое лекарство, а старый, дешевый как чипсы стероид. Это то, что нужно праздновать, потому что пациенты во всем мире могут получить пользу немедленно.

Dexamethasone has been used since the early 1960s to treat a wide range of diseases, such as rheumatoid arthritis and asthma. Half of all Covid patients who require mechanical ventilation do not survive, therefore reducing this risk by a third would have a huge impact.

The drug is administered intravenously in intensive care and in the form of tablets for less seriously ill patients. To date, the only other drug that has been proven to benefit COVID-19 patients is remdesivir, which has been used to treat Ebola. It reduces the duration of coronavirus symptoms from 15 days to 11. But the data were not convincing enough to show whether mortality had decreased.

В отличие от дексаметазона, ремдесивир — это новый препарат с ограниченными запасами, и цена пока не объявлена.

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