The first drug completely created by artificial intelligence began to be tested on humans - ForumDaily
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The first drug completely created by artificial intelligence began to be tested on humans

Human clinical trials have recently begun for the first fully artificial intelligence (AI) drug. The edition told in more detail CNBC.

Photo: IStock

Insilico Medicine, a Hong Kong biotech startup with more than $400 million in funding, has created INS018_055 to treat idiopathic pulmonary fibrosis (IPF), a chronic disease that causes scarring of the lungs.

The condition, which has increased in prevalence in recent decades, currently affects about 100 people in the US and can lead to death within two to five years if left untreated, according to the National Institutes of Health.

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“This is the first fully generative medicine created by artificial intelligence to undergo clinical trials in humans, specifically Phase II trials in patients,” said Alex Zhavoronkov, founder and CEO of Insilico Medicine. “While there are other AI-designed drugs currently in trials, ours is the first drug with a new AI-discovered target and a new AI-generated design.”

The drug discovery process began in 2020 with the hope of creating something to overcome problems with current treatments for IPF, Zhavoronkov said. They mainly focus on slowing progression and can cause unpleasant side effects.

He explained that Insilico chose to focus on IPF in part because of the condition's impact on aging, but that the company has two other drugs that are partly AI-generated at the clinical stage. One is a COVID-19 drug in Phase I clinical trials, and the other is an anti-cancer drug, specifically a “USP1 inhibitor for tumor treatment,” which was recently approved by the Food and Drug Administration (FDA). to start clinical trials.

“When this campaign was launched, we focused on algorithms—the development of technology that could discover and design new molecules,” Zhavoronkov said. “In those early days, I never thought I would be using algorithms for artificial intelligence in clinical drug trials with patients. But we realized that to validate our AI platform, we not only needed to develop a new drug for a new target, but also put it into clinical trials to prove that our technology worked.”

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The current trial of IPF is a 12-week, randomized, double-blind, placebo-controlled trial in China, and Insilico plans to expand its testing cohort to 60 people at 40 centers in the US and China. If the current Phase XNUMX study is successful, it will move on to another study with a larger sample size and then possibly reach Phase XNUMX studies with hundreds of participants.

“We expect to receive the results of the current phase II study next year,” Zhavoronkov assured, adding that it is difficult to predict the exact timing of future phases, especially since the disease is relatively rare and patients must meet certain criteria.

He concluded: “We are optimistic that this drug will be ready to market and reach patients who can benefit from it in the next few years.”

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