'The biological clock has begun to reverse': scientists for the first time managed to rejuvenate people at the DNA level - ForumDaily
The article has been automatically translated into English by Google Translate from Russian and has not been edited.
Переклад цього матеріалу українською мовою з російської було автоматично здійснено сервісом Google Translate, без подальшого редагування тексту.
Bu məqalə Google Translate servisi vasitəsi ilə avtomatik olaraq rus dilindən azərbaycan dilinə tərcümə olunmuşdur. Bundan sonra mətn redaktə edilməmişdir.

'The biological clock has begun to reverse': scientists for the first time managed to rejuvenate people at the DNA level

Participants in a medical experiment conducted by scientists at the University of California became “younger” as a result of taking prescribed medications—that is, they lowered their biological age, determined by special DNA markers.

Фото: Depositphotos

The journal Nature reports this, calling the results of the experiment the first hint that the “biological age” of an organism can be reversed, writes Air force.

At the same time, the journal, like the authors of the study themselves, emphasize the very modest scope of work and the absence of a control group.

The fact is that scientists themselves did not expect such results and did not even set a similar goal: they only wanted to check the effect of the simultaneous administration of three drugs widely used in medicine on the immune system.

However, after a year of taking this medicinal cocktail by volunteers, it turned out that each of them “looked younger” by an average of 2,5 years.

Signs of recovery were also shown by the immune system of the participants.

“I expected to see a slowdown of the [biological] clock, but not a reversal,” Nature quotes one of the authors of the work, professor of genetics Steve Horvath. “It all looked pretty futuristic.”

On the subject: The class of immortal masters: how science and business try to conquer aging

Accidental discovery

A person's biological age is determined by the so-called epigenetic clock - a set of DNA markers that change as we age. It reflects the functional state of the body and can either be ahead of the real calendar age or lag behind it.

Aging biomarkers were discovered half a century ago, and since then many scientists have been trying to come up with a way to slow down the biological clock to prolong youth.

However, the experiment conducted at Stanford Medical Center was set for a completely different purpose. Initially, an immunologist from Los Angeles, Gregory Fahi, wanted to test how safe it is to use injections of growth hormone (growth hormone) to restore the tissues of the thymus gland in humans.

This small organ is located in the upper part of the chest and plays a crucial role in the immune system, but with age it begins to shrink and become clogged with adipose tissue.

Some studies - mainly in animals - have shown that growth hormone helps the regeneration of the thymus gland, but at the same time contributes to the development of diabetes. Therefore, along with somatotropin injections, the experiment participants were prescribed two well-known antidiabetic drugs - prasterone and metformin.

Nine volunteers, all white men aged 51 to 65, had regular blood tests taken over the course of a year and MRI scans at the start and end of the study.

As a result, blood counts improved in all nine participants, and in seven of them, regeneration of thymus gland tissue actually occurred - that is, Fahy’s experiment was a success.

On the subject: Ice cream, chocolate and soda: the most elderly American woman told the secrets of longevity

Only then did the scientist come up with the idea of ​​showing the results of his work to Steve Horvath, the developer of one of the most accurate ways to measure biological age.

Horvath conducted his own research and found that the biological age of all participants in the experiment decreased significantly. Including those six volunteers who took their last blood test six months after finishing taking the drugs - that is, the “age-related effect” of therapy turned out to be long-lasting.

Now it needs to be tested in the course of a special, larger-scale study.

“There may be some effect, but these results cannot be considered absolutely reliable, because the scale of the work is very modest and the control over the study was not sufficient,” emphasizes Wolfgang Wagner, professor of cell biology at the University of Aachen.

However, Horvath himself is optimistic: “Because we were able to track the changes [in the analyzes] of each participant separately, and for everyone the effect [of rejuvenation] was very strong, I am full of optimism.”

Read also on ForumDaily:

Her secret to youth: 100-year-old American became a yoga guru

In the USA, the business of 'rejuvenation' through the infusion of someone else's blood is growing

Israel has identified seven commandments of longevity: what you need to live to 100+ years

Miscellanea DNA youth aging Educational program
Subscribe to ForumDaily on Google News

Do you want more important and interesting news about life in the USA and immigration to America? — support us donate! Also subscribe to our page Facebook. Select the “Priority in display” option and read us first. Also, don't forget to subscribe to our РєР ° РЅР ° Р »РІ Telegram  and Instagram- there is a lot of interesting things there. And join thousands of readers ForumDaily New York — there you will find a lot of interesting and positive information about life in the metropolis. 



 
1067 requests in 1,271 seconds.